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Medications used to treat fibromyalgia

The drugs amitriptyline, duloxetine, milnacipran, and pregabalin can relieve fibromyalgia pain in some people. You may experience side effects such as dry mouth or nausea. Normal pain relievers like acetaminophen or paracetamol are not recommended for fibromyalgia.

There is currently no drug that has been specifically developed and approved for the treatment of fibromyalgia. However, certain drugs that are approved to treat other chronic pain or other conditions can sometimes help with fibromyalgia. Studies show this for the following four drugs:

  • Amitriptyline
  • Duloxetine
  • Milnacipran
  • Pregabalin

With the exception of amitriptyline, the use of these drugs is, from a legal point of view, non-intended use (off-label use), for which special regulations apply - for example, the assumption of costs. It is different if someone has another disease in addition to fibromyalgia for which the respective drug is approved, such as one. It may take a few weeks for the medication to take effect.

It makes sense not to rely on drugs alone, but to combine them with other treatments. Light physical activity can alleviate the symptoms and improve resilience. How to deal with the disease is also important - for example, reducing stress and planning everyday life in such a way that you do not overuse yourself if possible.